Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Copyright policy )Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Significance Understanding loci nominated by genome-wide association studies (GWASs) is challenging. Here, we show, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci. This result illustrates a significant general principle that will likely apply across multiple diseases.
- University of Southampton United Kingdom
- University of Bristol United Kingdom
- University College London United Kingdom
- University of Tübingen Germany
- National Institute of Health Pakistan
Blotting, Western, 610, Golgi Apparatus, Cell Fractionation, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mass Spectrometry, Humans, Immunoprecipitation, Genetic Predisposition to Disease, Adaptor Proteins, Signal Transducing, DNA Primers, Analysis of Variance, Microscopy, Confocal, Intracellular Signaling Peptides and Proteins, Brain, Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience, Parkinson Disease, name=SDG 3 - Good Health and Well-being, HEK293 Cells, Genetic Loci, Multiprotein Complexes, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, Genome-Wide Association Study, Plasmids
Blotting, Western, 610, Golgi Apparatus, Cell Fractionation, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mass Spectrometry, Humans, Immunoprecipitation, Genetic Predisposition to Disease, Adaptor Proteins, Signal Transducing, DNA Primers, Analysis of Variance, Microscopy, Confocal, Intracellular Signaling Peptides and Proteins, Brain, Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience, Parkinson Disease, name=SDG 3 - Good Health and Well-being, HEK293 Cells, Genetic Loci, Multiprotein Complexes, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, Genome-Wide Association Study, Plasmids
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