Getting knotted: a model for the structure and activation of Spätzle
Copyright policy )Getting knotted: a model for the structure and activation of Spätzle
Sequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization.
- University of Cambridge United Kingdom
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Blood Proteins, Drosophila melanogaster, Animals, Drosophila Proteins, Insect Proteins, Amino Acid Sequence, Nerve Growth Factors
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Blood Proteins, Drosophila melanogaster, Animals, Drosophila Proteins, Insect Proteins, Amino Acid Sequence, Nerve Growth Factors
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