Tauopathies and synucleinopathies: Do cerebrospinal fluid β-amyloid peptides reflect disease-specific pathogenesis?
Copyright policy )Tauopathies and synucleinopathies: Do cerebrospinal fluid β-amyloid peptides reflect disease-specific pathogenesis?
To evaluate variations in amyloid beta (Abeta) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently established quantitative urea-based Abeta-sodium-dodecylsulfate-polyacrylamide-gel-electrophoresis with western immunoblot (Abeta-SDS-PAGE/immunoblot) revealed a highly conserved Abeta peptide (Abeta1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in Abeta-processing. We used the Abeta-SDS-PAGE/immunoblot to investigate CSF for disease-specific Abeta peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer's disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n = 12), Parkinson's disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19). The Abeta peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and alpha-synuclein on Abeta-processing.
- University of Göttingen Germany
- University of Ulm Germany
- University of Erlangen-Nuremberg Germany
- Brigham and Women's Faulkner Hospital United States
Aged, 80 and over, Male, Amyloid beta-Peptides, tau Proteins, Middle Aged, Multiple System Atrophy, Tauopathies, Alzheimer Disease, alpha-Synuclein, Humans, Female, Protein Processing, Post-Translational, Aged
Aged, 80 and over, Male, Amyloid beta-Peptides, tau Proteins, Middle Aged, Multiple System Atrophy, Tauopathies, Alzheimer Disease, alpha-Synuclein, Humans, Female, Protein Processing, Post-Translational, Aged
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