HLA-DRB1 frequencies of the Comorian population and their genetic affinities with Sub-Saharan African and Indian Oceanian populations
pmid: 17092866
HLA-DRB1 frequencies of the Comorian population and their genetic affinities with Sub-Saharan African and Indian Oceanian populations
Ethnic-historic sources have considered the Comorian population to be the result of an amalgamation of African, Arabian and Southeast Asian groups.This study seeks to determine the genetic relationships and contributions from Sub-Saharan Africa and Indian Oceania and to reconstruct past migration events.The human leukocyte antigen (HLA) polymorphism of a Comorian population was described and analysed.Genetic distances and multidimensional scaling analyses showed complex patterns of genetic differentiation in the Indian Oceanian area as a result of continuous gene flow occurring within the past approximately 2500 years. Nevertheless, the Comorian genetic pool appears to be a mix of Bantu-speaking and Arab populations as testified to by admixture estimations of almost 50-60% and 27-33%, respectively.The Comorian population may represent the eastern limit of the recent and massive eastward Bantu expansion. In contrast to the population from Madagascar (Merina), only a restricted influence of Austronesian populations was found.
Polymorphism, Genetic, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, HLA-DR Antigens, East Africa, [SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology, HLA, [SDE.BE] Environmental Sciences/Biodiversity and Ecology, Genetics, Population, Gene Frequency, Indian Ocean Islands, Comoro Islands, Humans, Bantu, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Africa South of the Sahara, HLA-DRB1 Chains
Polymorphism, Genetic, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, HLA-DR Antigens, East Africa, [SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology, HLA, [SDE.BE] Environmental Sciences/Biodiversity and Ecology, Genetics, Population, Gene Frequency, Indian Ocean Islands, Comoro Islands, Humans, Bantu, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Africa South of the Sahara, HLA-DRB1 Chains
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