Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor
Copyright policy )Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor
Recent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor.
- University of Hong Kong China (People's Republic of)
- Yonsei University Health System Korea (Republic of)
- Yonsei University Medical Library Korea (Republic of)
- Niigata University Japan
- Yonsei University Korea (Republic of)
Proto-Oncogene Proteins - Genetics - Metabolism, Epithelium - Embryology - Growth & Development - Metabolism, 590, Embryonic Stem Cells - Metabolism, Signal Transducing/genetics*, Atp-Binding Cassette Transporters - Genetics - Metabolism, Cell Cycle Proteins, Epithelium, Mice, Octamer Transcription Factor-3/genetics*, Dental Papilla - Embryology - Growth & Development - Metabolism, ATP Binding Cassette Transporter, Subfamily G, Member 2, Developmental, Bmi-1, Dental Papilla/growth & development, Octamer Transcription Factor-3/metabolism, Polycomb Repressive Complex 1, Mice, Inbred Icr, Mice, Inbred ICR, Epithelium/embryology, Nuclear Proteins/genetics*, Signal Transducing/metabolism, Repressor Proteins - Genetics - Metabolism, Signal Transducing - Genetics - Metabolism, Adaptor Proteins, Gene Expression Regulation, Developmental, Nuclear Proteins, Inbred ICR, Inbred Icr, Incisor/embryology*, ATP-Binding Cassette Transporters/genetics*, Phosphoproteins/metabolism, Incisor, Female, Yap, Member 2, 570, Incisor - Embryology - Growth & Development - Metabolism, ATP Binding Cassette Transporter, ABCG2, Phosphoproteins/genetics*, Embryonic Stem Cells/metabolism, 610, Dental Papilla/embryology, Tooth development, Incisor/growth & development*, Proto-Oncogene Proteins, Animals, Dental Papilla/metabolism, ATP-Binding Cassette Transporters/metabolism, Antigens, Dental Papilla, Sub-Family G, Embryonic Stem Cells, Nuclear Proteins/metabolism, Adaptor Proteins, Signal Transducing, Incisor/metabolism, Oct-3/4, Repressor Proteins/metabolism, Proto-Oncogene Proteins/genetics*, Octamer Transcription Factor-3 - Genetics - Metabolism, Epithelium/growth & development, Differentiation - Metabolism, Antigens, Differentiation - Metabolism, Proto-Oncogene Proteins/metabolism, Phosphoproteins, Antigens, Differentiation, Repressor Proteins/genetics*, Adaptor Proteins, Signal Transducing - Genetics - Metabolism, Epithelium/metabolism, Repressor Proteins, Gene Expression Regulation, ATP-Binding Cassette Transporters, Nuclear Proteins - Genetics - Metabolism, Octamer Transcription Factor-3, Differentiation/metabolism, Phosphoproteins - Genetics - Metabolism
Proto-Oncogene Proteins - Genetics - Metabolism, Epithelium - Embryology - Growth & Development - Metabolism, 590, Embryonic Stem Cells - Metabolism, Signal Transducing/genetics*, Atp-Binding Cassette Transporters - Genetics - Metabolism, Cell Cycle Proteins, Epithelium, Mice, Octamer Transcription Factor-3/genetics*, Dental Papilla - Embryology - Growth & Development - Metabolism, ATP Binding Cassette Transporter, Subfamily G, Member 2, Developmental, Bmi-1, Dental Papilla/growth & development, Octamer Transcription Factor-3/metabolism, Polycomb Repressive Complex 1, Mice, Inbred Icr, Mice, Inbred ICR, Epithelium/embryology, Nuclear Proteins/genetics*, Signal Transducing/metabolism, Repressor Proteins - Genetics - Metabolism, Signal Transducing - Genetics - Metabolism, Adaptor Proteins, Gene Expression Regulation, Developmental, Nuclear Proteins, Inbred ICR, Inbred Icr, Incisor/embryology*, ATP-Binding Cassette Transporters/genetics*, Phosphoproteins/metabolism, Incisor, Female, Yap, Member 2, 570, Incisor - Embryology - Growth & Development - Metabolism, ATP Binding Cassette Transporter, ABCG2, Phosphoproteins/genetics*, Embryonic Stem Cells/metabolism, 610, Dental Papilla/embryology, Tooth development, Incisor/growth & development*, Proto-Oncogene Proteins, Animals, Dental Papilla/metabolism, ATP-Binding Cassette Transporters/metabolism, Antigens, Dental Papilla, Sub-Family G, Embryonic Stem Cells, Nuclear Proteins/metabolism, Adaptor Proteins, Signal Transducing, Incisor/metabolism, Oct-3/4, Repressor Proteins/metabolism, Proto-Oncogene Proteins/genetics*, Octamer Transcription Factor-3 - Genetics - Metabolism, Epithelium/growth & development, Differentiation - Metabolism, Antigens, Differentiation - Metabolism, Proto-Oncogene Proteins/metabolism, Phosphoproteins, Antigens, Differentiation, Repressor Proteins/genetics*, Adaptor Proteins, Signal Transducing - Genetics - Metabolism, Epithelium/metabolism, Repressor Proteins, Gene Expression Regulation, ATP-Binding Cassette Transporters, Nuclear Proteins - Genetics - Metabolism, Octamer Transcription Factor-3, Differentiation/metabolism, Phosphoproteins - Genetics - Metabolism
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