Local Cardiac Renin–Angiotensin System: Hypertension and Cardiac Failure
Copyright policy )Local Cardiac Renin–Angiotensin System: Hypertension and Cardiac Failure
In addition to the effect on arterial pressure, angiotensin II, the effector peptide of the renin-angiotensin system (RAS), exerts mitogenic and growth promoting effects on cardiac myocytes and non-myocytic elements; and both of these effects significantly contribute to the development and progression of hypertensive heart disease (HHD). The traditional concept of the RAS as a systemic, endocrine system has been expanded and the identification of its components in many organs and tissue has been amassed. This paper reviews evidence that supports the concept that the cardiac RAS participate importantly in the development and risk of HHD.
Heart Failure, Ventricular Remodeling, Angiotensin II, Myocardium, Hemodynamics, Angiotensin-Converting Enzyme Inhibitors, Heart, Rats, Animals, Genetically Modified, Renin-Angiotensin System, Organ Specificity, Rats, Inbred SHR, Hypertension, Animals, Humans, Hypertrophy, Left Ventricular, Vascular Resistance, Aldosterone, Antihypertensive Agents
Heart Failure, Ventricular Remodeling, Angiotensin II, Myocardium, Hemodynamics, Angiotensin-Converting Enzyme Inhibitors, Heart, Rats, Animals, Genetically Modified, Renin-Angiotensin System, Organ Specificity, Rats, Inbred SHR, Hypertension, Animals, Humans, Hypertrophy, Left Ventricular, Vascular Resistance, Aldosterone, Antihypertensive Agents
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