Association study between clinical response to rizatriptan and some candidate genes
Copyright policy )Association study between clinical response to rizatriptan and some candidate genes
The aim of this study was to test genetic differences in the clinical response to rizatriptan in patients affected by migraine without aura. These genetic differences could be explained by various genes, the HTR1B, encoding the 5-HT(1) receptor subtype, MAOA gene that encodes the monoamino-oxidase, the main metabolic enzyme of this triptan, SLC6A4 (gene encoding the serotonin transporter) and DRD(2) (gene encoding the D(2) receptor), both involved in the pathogenesis of migraine. Fifty unrelated patients affected by migraine without aura (IHS) were included. Patients were divided into two groups (responders and non-responders) according to clinical response. Thirty-one out of fifty patients responded to rizatriptan. A significant difference among the two groups was observed in both allele (p=0.02) and genotype distribution (p=0.03) of DRD2/NcoI. The significant association with the DRD2/NcoI polymorphism in responders suggested that the DRD2/NcoI C allele may be considered a susceptibility factor heralding a good response to rizatriptan.
- University of Cagliari Italy
Adult, Male, Migraine without Aura, Genotype, Clinical Neurology, Drug Resistance, Humans, Prospective Studies, Monoamine Oxidase, Alleles, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, Receptors, Dopamine D2, Reverse Transcriptase Polymerase Chain Reaction, Middle Aged, Triazoles, Tryptamines, Serotonin Receptor Agonists, Anesthesiology and Pain Medicine, Treatment Outcome, Receptor, Serotonin, 5-HT1B, Female, Rapid Communication
Adult, Male, Migraine without Aura, Genotype, Clinical Neurology, Drug Resistance, Humans, Prospective Studies, Monoamine Oxidase, Alleles, Serotonin Plasma Membrane Transport Proteins, Polymorphism, Genetic, Receptors, Dopamine D2, Reverse Transcriptase Polymerase Chain Reaction, Middle Aged, Triazoles, Tryptamines, Serotonin Receptor Agonists, Anesthesiology and Pain Medicine, Treatment Outcome, Receptor, Serotonin, 5-HT1B, Female, Rapid Communication
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).24 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!