Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation
Copyright policy )Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation
The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-A∗24:02-positive patient, who failed to eliminate CMV for more than 1 year after HSCT, responded poorly to CMV pp65 peptide and showed high PD-1 expression. Sera from patients with persistent CMV infection showed a significantly higher IL-6 level than those from patients with temporary CMV infection after allogeneic HSCT and healthy donors. CD33+ adherent cells produced IL-6, and regulated PD-1 expression and growth of CMV-specific CD8+ T cells through cell-to-cell contact. Although further investigation is required to clarify the association between IL-6 level and CMV infection in more patients, IL-6 might be a useful biomarker of persistent CMV infection after allogeneic HSCT.
Male, Interleukin-6, Programmed Cell Death 1 Receptor, Sialic Acid Binding Ig-like Lectin 3, Hematopoietic Stem Cell Transplantation, Cytomegalovirus, Gene Expression, HLA-A24 Antigen, Cell Communication, CD8-Positive T-Lymphocytes, Middle Aged, Viral Load, Cytomegalovirus Infections, Host-Pathogen Interactions, Cell Adhesion, Immune Tolerance, Humans, Transplantation, Homologous, Signal Transduction
Male, Interleukin-6, Programmed Cell Death 1 Receptor, Sialic Acid Binding Ig-like Lectin 3, Hematopoietic Stem Cell Transplantation, Cytomegalovirus, Gene Expression, HLA-A24 Antigen, Cell Communication, CD8-Positive T-Lymphocytes, Middle Aged, Viral Load, Cytomegalovirus Infections, Host-Pathogen Interactions, Cell Adhesion, Immune Tolerance, Humans, Transplantation, Homologous, Signal Transduction
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