The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis
Copyright policy )The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis
The ubiquitin‐editing enzyme A20 suppresses nuclear factor‐κB (NF‐κB) activation and tumor necrosis factor‐α (TNF‐α)‐induced apoptosis in a deubiquitinating and ubiquitin ligase activity‐dependent manner. Although recent studies revealed that A20 regulates NF‐κB independently of its enzymatic activity through its seventh zinc finger motif (ZnF7), the involvement of ZnF7 in TNF‐α‐induced apoptosis is not clear. In this study, ZnF7 was found to be important for A20‐mediated suppression of TNF‐α‐induced apoptosis. We also found that the ubiquitin ligases cIAP1/2 are required for A20 to suppress TNF‐α‐induced apoptosis. Because A20 binds to cIAP1/2 through ZnF7, these results suggest that A20 may control cIAP1/2 when suppressing TNF‐α‐induced apoptosis.
- Chiba University Japan
Cell Survival, Apoptosis, Cell Line, Inhibitor of Apoptosis Proteins, Mice, Interleukin-1alpha, Animals, Humans, Enzyme Inhibitors, Tumor Necrosis Factor alpha-Induced Protein 3, Ubiquitin, Tumor Necrosis Factor-alpha, Intracellular Signaling Peptides and Proteins, NF-kappa B, Nuclear Proteins, Nuclear factor-κB, Baculoviral IAP Repeat-Containing 3 Protein, Recombinant Proteins, Tumor necrosis factor-α, DNA-Binding Proteins, Cysteine Endopeptidases, Amino Acid Substitution, Mutant Proteins
Cell Survival, Apoptosis, Cell Line, Inhibitor of Apoptosis Proteins, Mice, Interleukin-1alpha, Animals, Humans, Enzyme Inhibitors, Tumor Necrosis Factor alpha-Induced Protein 3, Ubiquitin, Tumor Necrosis Factor-alpha, Intracellular Signaling Peptides and Proteins, NF-kappa B, Nuclear Proteins, Nuclear factor-κB, Baculoviral IAP Repeat-Containing 3 Protein, Recombinant Proteins, Tumor necrosis factor-α, DNA-Binding Proteins, Cysteine Endopeptidases, Amino Acid Substitution, Mutant Proteins
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