Transcriptional Regulation of the Human E-Cadherin Gene in Human Prostate Cancer Cell Lines: Characterization of the Human E-Cadherin Gene Promoter
Copyright policy )Transcriptional Regulation of the Human E-Cadherin Gene in Human Prostate Cancer Cell Lines: Characterization of the Human E-Cadherin Gene Promoter
Decreased expression of the Ca(2+)-dependent cell adhesion molecule E-cadherin is observed in several poorly differentiated carcinomas and is presumably associated with an invasive phenotype of these tumors. Evidence accumulated so far indicates that decreased transcription is a major mechanism leading to defective E-cadherin function. Therefore, we isolated and characterized the human E-cadherin gene promoter and studied the transcriptional regulation of this gene in two human prostate cancer cell lines, one expressing E-cadherin (PC-3), the other one not expressing E-cadherin (TSU-pr1). We show that the E-cadherin promoter is not active in the non-expressing cells and that this may be due to the binding of a repressor protein to the promoter.
Male, Base Sequence, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Single-Strand Specific DNA and RNA Endonucleases, Prostate, Cadherins, TATA Box, Cell Line, Gene Expression Regulation, Cell Adhesion, Humans, Calcium, Promoter Regions, Genetic
Male, Base Sequence, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Single-Strand Specific DNA and RNA Endonucleases, Prostate, Cadherins, TATA Box, Cell Line, Gene Expression Regulation, Cell Adhesion, Humans, Calcium, Promoter Regions, Genetic
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