Taste-independent nutrient selection is mediated by a brain-specific Na+/solute co-transporter in Drosophila
Copyright policy )Taste-independent nutrient selection is mediated by a brain-specific Na+/solute co-transporter in Drosophila
Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.
- New York University United States
Neurons, Analysis of Variance, Base Sequence, Dose-Response Relationship, Drug, CD8 Antigens, Green Fluorescent Proteins, Brain, Choice Behavior, Article, Animals, Genetically Modified, Food Preferences, Glucose, Gene Expression Regulation, Hemolymph, Mutation, Animals, Drosophila Proteins, Humans, Drosophila, Food Deprivation, Glycogen
Neurons, Analysis of Variance, Base Sequence, Dose-Response Relationship, Drug, CD8 Antigens, Green Fluorescent Proteins, Brain, Choice Behavior, Article, Animals, Genetically Modified, Food Preferences, Glucose, Gene Expression Regulation, Hemolymph, Mutation, Animals, Drosophila Proteins, Humans, Drosophila, Food Deprivation, Glycogen
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