CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas
Copyright policy )CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas
HSV-1 ocular infections are the leading cause of corneal blindness. Eye disease is the result of a prolonged immune response to the replicating virus. HSV-1, on the other hand, has evolved several mechanisms to evade clearance by the host immune system. We describe a novel mechanism of HSV-1 immune evasion via ICP22-dependent downregulation of the host T cell costimulatory molecule CD80. However, the exact role of CD80 in HSV-1 immune pathology is not clear. In this study, we show that eye disease is independent of the level of HSV-1 replication and that viral expression of CD80 has a detrimental role in corneal scarring, likely by increasing CD8+T cell recruitment and activation.
- Cedars-Sinai Medical Center United States
Inflammation, Mice, Inbred BALB C, RNA-Binding Proteins, Dendritic Cells, Herpesvirus 1, Human, CD8-Positive T-Lymphocytes, Cornea, Mice, B7-1 Antigen, Keratitis, Herpetic, Animals, Female, Rabbits, Apoptosis Regulatory Proteins, Interleukin-1, Signal Transduction
Inflammation, Mice, Inbred BALB C, RNA-Binding Proteins, Dendritic Cells, Herpesvirus 1, Human, CD8-Positive T-Lymphocytes, Cornea, Mice, B7-1 Antigen, Keratitis, Herpetic, Animals, Female, Rabbits, Apoptosis Regulatory Proteins, Interleukin-1, Signal Transduction
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