Mannosylated PLP139–151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis
Copyright policy )Mannosylated PLP139–151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis
SJL mice immunized with mannosylated (M-) PLP(139-151) in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP(139-151)-immunized mice show impaired delayed-type-sensitivity to PLP(139-151) but a normal response to other peptides. After re-immunization with PLP(139-151) in complete adjuvant, these mice are largely tolerant to EAE, show less T cell proliferation and decreased peptide-specific IgG2a. Our data suggest that M-PLP(139-151) induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells.
- Delft University of Technology Netherlands
- Leiden University Medical Center Netherlands
Mannose-receptor, Central Nervous System, myelin proteolipid protein[139-151], Encephalomyelitis, Autoimmune, Experimental, cell migration, Injections, Subcutaneous, animal experiment, Molecular Sequence Data, animal cell, delayed hypersensitivity, immunization, Severity of Illness Index, animal tissue, immunoglobulin G2, Mice, allergic encephalomyelitis, proteolipid protein, Cell Movement, T lymphocyte, Animals, C-type lectins, controlled study, Hypersensitivity, Delayed, Amino Acid Sequence, Myelin Proteolipid Protein, mouse, Cells, Cultured, nonhuman, EAE, Immunodominant Epitopes, animal model, drug effect, Th1 Cells, Peptide Fragments, unclassified drug, drug efficacy, cell proliferation, female, Self Tolerance, priority journal, Leukocytes, Mononuclear, Female, Tolerance, Mannose
Mannose-receptor, Central Nervous System, myelin proteolipid protein[139-151], Encephalomyelitis, Autoimmune, Experimental, cell migration, Injections, Subcutaneous, animal experiment, Molecular Sequence Data, animal cell, delayed hypersensitivity, immunization, Severity of Illness Index, animal tissue, immunoglobulin G2, Mice, allergic encephalomyelitis, proteolipid protein, Cell Movement, T lymphocyte, Animals, C-type lectins, controlled study, Hypersensitivity, Delayed, Amino Acid Sequence, Myelin Proteolipid Protein, mouse, Cells, Cultured, nonhuman, EAE, Immunodominant Epitopes, animal model, drug effect, Th1 Cells, Peptide Fragments, unclassified drug, drug efficacy, cell proliferation, female, Self Tolerance, priority journal, Leukocytes, Mononuclear, Female, Tolerance, Mannose
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