Significance Inositol phosphate kinase 2 (Ipk2) is a conserved protein that initiates the production of inositol phosphate intracellular messengers that are critical for regulating a variety of cellular processes. Here we explore the developmental roles Ipk2 and its products in Drosophila . We report that Ipk2 kinase activity is required to develop adult body structures including eyes, legs, and wings, which are formed by tissue known as imaginal discs. Although Ipk2 mutant discs seem to pattern normally in embryogenesis, during larval development they fail to undergo normal expansion. We find defects in signaling pathways that control both cell death and proliferation. Our work demonstrates a specific role for Ipk2-produced intracellular messengers in regulating developmental pathways involved in tissue growth and stability.