CRTH2 Is Not Involved in the Anti-Enteropooling Effect of PGD<sub>2</sub> in the Small Intestine
Copyright policy )CRTH2 Is Not Involved in the Anti-Enteropooling Effect of PGD<sub>2</sub> in the Small Intestine
The majority of prostaglandins (PGs) are known to induce intestinal fluid secretion (enteropooling). In contrast, PGD<sub>2</sub> has been demonstrated to inhibit fluid secretion induced by other PGs. This study was aimed to investigate, by the use of selective agonists/antagonists, which type of PGD<sub>2</sub> receptor mediates this inhibitory effect. The DP1 agonist BW245C dose-dependently inhibited the enteropooling effect of 16,16-dimethyl-PGE<sub>2</sub>. This inhibition was counteracted by the DP1 antagonist BWA868C. In contrast, the CRTH2 receptor does not seem to be involved in the anti-enteropooling effect of PGD<sub>2</sub>, since the selective agonists 13,14-dihydro-15-keto-PGD<sub>2</sub> and 15(R)-15-methyl-PGD<sub>2</sub> were without effect. Therefore, our results suggest that the inhibitory effect of PGD<sub>2</sub> in the small intestine is mediated via activation of the DP1 receptor.
- Medical University of Graz Austria
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!