Quality Control: Another Player Joins the ERAD Cast
Copyright policy )Quality Control: Another Player Joins the ERAD Cast
The quality control system known as ERAD removes misfolded proteins from the ER to the cytosol for degradation. The AAA ATPase Cdc48p and ubiquitin ligases play crucial roles; their relationship has been unclear, but recent work has shown that the membrane protein Ubx2p links their functions in yeast.
- University of Warwick United Kingdom
- University of Salford United Kingdom
Adenosine Triphosphatases, Nucleocytoplasmic Transport Proteins, Proteasome Endopeptidase Complex, Protein Folding, Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Ubiquitin-Protein Ligases, Vesicular Transport Proteins, Cell Cycle Proteins, Endoplasmic Reticulum, Nuclear Pore Complex Proteins, Valosin Containing Protein, Yeasts, Peptides
Adenosine Triphosphatases, Nucleocytoplasmic Transport Proteins, Proteasome Endopeptidase Complex, Protein Folding, Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Ubiquitin-Protein Ligases, Vesicular Transport Proteins, Cell Cycle Proteins, Endoplasmic Reticulum, Nuclear Pore Complex Proteins, Valosin Containing Protein, Yeasts, Peptides
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