TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation
Copyright policy )TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation
Through their interaction with the TNF receptor–associated factor (TRAF) family, members of the tumor necrosis factor receptor (TNFR) superfamily elicit a wide range of biological effects including differentiation, proliferation, activation, or cell death. We have identified and characterized a novel component of the receptor–TRAF signaling complex, designated TRIP (TRAF-interacting protein), which contains a RING finger motif and an extended coiled-coil domain. TRIP associates with the TNFR2 or CD30 signaling complex through its interaction with TRAF proteins. When associated, TRIP inhibits the TRAF2-mediated NF-κB activation that is required for cell activation and also for protection against apoptosis. Thus, TRIP acts as a receptor–proximal regulator that may influence signals responsible for cell activation/proliferation and cell death induced by members of the TNFR superfamily.
- Rockefeller University United States
- Howard Hughes Medical Institute United States
Binding Sites, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, NF-kappa B, Gene Expression Regulation, Developmental, Ki-1 Antigen, Proteins, Sequence Analysis, DNA, TNF Receptor-Associated Factor 2, Models, Biological, TNF Receptor-Associated Factor 1, Protein Structure, Secondary, Receptors, Tumor Necrosis Factor, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, Tissue Distribution, Amino Acid Sequence, Cloning, Molecular, Protein Binding, Signal Transduction
Binding Sites, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, NF-kappa B, Gene Expression Regulation, Developmental, Ki-1 Antigen, Proteins, Sequence Analysis, DNA, TNF Receptor-Associated Factor 2, Models, Biological, TNF Receptor-Associated Factor 1, Protein Structure, Secondary, Receptors, Tumor Necrosis Factor, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, Tissue Distribution, Amino Acid Sequence, Cloning, Molecular, Protein Binding, Signal Transduction
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