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Myocardial sarcoplasmic reticulum Ca2+ATPase function is increased by aerobic interval training

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2008 English Publisher:Oxford University Press (OUP)Journal:European Journal of Cardiovascular Prevention & Rehabilitation, volume 15, pages 145-148 (issn: 1741-8267,

Authors: Godfrey L. Smith; Marcello Ceci; Gianluigi Condorelli; Ole J. Kemi; Ole J. Kemi; Ulrik Wisløff;

doi: 10.1097/hjr.0b013e3282efd4e0

pmid: 18391639

Myocardial sarcoplasmic reticulum Ca2+ATPase function is increased by aerobic interval training

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Abstract

Reduced activity of the sarcoplasmic reticulum Ca ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training.SERCA-2a function was assessed by sarcoplasmic reticulum Ca uptake in cardiomyocytes with other Ca uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls.We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio.Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca-handling improves after exercise training.

Related Organizations

University of California, San Diego
United States
University of Glasgow
United Kingdom
Institute of Biomedical Science
United Kingdom
Norwegian University of Science and Technology
Norway

Keywords

Calcium-Binding Proteins, Physical Exertion, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Up-Regulation, Mice, Inbred C57BL, Mice, Sarcoplasmic Reticulum, Microscopy, Fluorescence, Animals, Calcium, Female, Myocytes, Cardiac, Fura-2, Fluorescent Dyes

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