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Developmental Biology
Article
License: Elsevier Non-Commercial
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Developmental Biology
Article . 2011
License: Elsevier Non-Commercial
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Developmental Biology
Article . 2011 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
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Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway

Authors: Rameen S. Moridzadeh; Chong T. Ying; Paola A. Ortiz; Shigeo Takashima; Volker Hartenstein; Amelia Younossi-Hartenstein; Katrina L. Adams;

Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway

Abstract

In this paper we have investigated the developmental-genetic steps that shape the entero-endocrine system of Drosophila melanogaster from the embryo to the adult. The process starts in the endoderm of the early embryo where precursors of endocrine cells and enterocytes of the larval midgut, as well as progenitors of the adult midgut, are specified by a Notch signaling-dependent mechanism. In a second step that occurs during the late larval period, enterocytes and endocrine cells of a transient pupal midgut are selected from within the clusters of adult midgut progenitors. As in the embryo, activation of the Notch pathway triggers enterocyte differentiation and inhibits cells from further proliferation or choosing the endocrine fate. The third step of entero-endocrine cell development takes place at a mid-pupal stage. Before this time point, the epithelial layer destined to become the adult midgut is devoid of endocrine cells. However, precursors of the intestinal midgut stem cells (pISCs) are already present. After an initial phase of symmetric divisions which causes an increase in their own population size, pISCs start to spin off cells that become postmitotic and express the endocrine fate marker, Prospero. Activation of Notch in pISCs forces these cells into an enterocyte fate. Loss of Notch function causes an increase in the proliferatory activity of pISCs, as well as a higher ratio of Prospero-positive cells.

Related Organizations
Keywords

Male, Notch, Entero-endocrine cell, Neurogenesis, Endocrine System, Models, Biological, Enteric Nervous System, Animals, Genetically Modified, Midgut, Morphogenesis, Animals, Drosophila Proteins, Cell Lineage, Intestinal Mucosa, Molecular Biology, Cell Proliferation, Stem cell, Receptors, Notch, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Cell Differentiation, Cell Biology, Intestines, Drosophila melanogaster, Enterocytes, Drosophila, Female, Developmental Biology

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
75
Top 10%
Top 10%
Top 10%
hybrid