Genome-wide association study identifies TPH2 variant as a novel locus for severe CV-A6-associated hand, foot, and mouth disease in Han Chinese
Copyright policy )Genome-wide association study identifies TPH2 variant as a novel locus for severe CV-A6-associated hand, foot, and mouth disease in Han Chinese
Little is known about the association between genetic susceptibility and the severity of hand, foot, and mouth disease (HFMD) infected with coxsackievirus A6 (CV-A6).Three hundred and sixty-four CV-A6 HFMD patients were enrolled, including 115 severe and 249 mild patients. A genome-wide association study (GWAS) was performed involving eight DNA pools of 115 severe and 115 mild CV-A6 HFMD patients pair-matched by age and gender. Differences in relative allele signal scores of SNPs in Illumina Human OmniZhongHua-8 BeadChips were compared between the two groups. The tag SNPS for potentially functional SNPs or their high linked SNPs were selected for individual genotyping in all 364 patients and assessed for their associations with severe CV-A6 HFMD using multivariable logistic regression analyses.The top 30 significant SNPs obtained from pooled DNA GWAS analysis were checked for biological functions and their high linkage disequilibrium (LD) SNPs. Four tag SNPs (rs1558206, rs6927647, rs9375728 and rs10879355) were selected for further individual genotyping in 364 CV-A6 patients. Only SNP rs10879355 was associated with severe CV-A6 HFMD, with CC genotype having a greater risk of severe illness than TT+TC genotypes (OR=2.48, 95%CI: 1.34, 4.56). SNP rs4290270 is in complete LD with rs10879355 in Chinese Han children.This is the first report that one potentially functional SNP rs4290270 in the TPH2 gene may be associated with the risk of severe CV-A6 HFMD.
- Huazhong University of Science and Technology China (People's Republic of)
- Centers for Disease Control and Prevention United States
Male, Genome-wide association study, China, Coxsackievirus 6, Genotype, Infectious and parasitic diseases, RC109-216, Tryptophan Hydroxylase, Polymorphism, Single Nucleotide, Humans, Genetic Predisposition to Disease, Child, Alleles, Severe, Infant, Enterovirus B, Human, Hand, foot, and mouth disease, Susceptibility, Child, Preschool, Female, Hand, Foot and Mouth Disease, Genome-Wide Association Study
Male, Genome-wide association study, China, Coxsackievirus 6, Genotype, Infectious and parasitic diseases, RC109-216, Tryptophan Hydroxylase, Polymorphism, Single Nucleotide, Humans, Genetic Predisposition to Disease, Child, Alleles, Severe, Infant, Enterovirus B, Human, Hand, foot, and mouth disease, Susceptibility, Child, Preschool, Female, Hand, Foot and Mouth Disease, Genome-Wide Association Study
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!