A Nurr1 Pathway for Neuroprotection
Copyright policy )A Nurr1 Pathway for Neuroprotection
Mutations in the gene encoding the orphan nuclear receptor Nurr1 are linked to a rare familial form of Parkinson's disease. By examining the function of its mouse homolog, Saijo et al. (2009) provide evidence that Nurr1 protects dopaminergic neurons by suppressing inflammatory gene expression in astrocytes and microglia.
DNA-Binding Proteins, Mice, Biochemistry, Genetics and Molecular Biology(all), Astrocytes, Nuclear Receptor Subfamily 4, Group A, Member 2, Animals, Parkinson Disease, Microglia, Signal Transduction, Transcription Factors
DNA-Binding Proteins, Mice, Biochemistry, Genetics and Molecular Biology(all), Astrocytes, Nuclear Receptor Subfamily 4, Group A, Member 2, Animals, Parkinson Disease, Microglia, Signal Transduction, Transcription Factors
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