Fuzzy protein theory for disordered proteins
Copyright policy )Fuzzy protein theory for disordered proteins
Why proteins are fuzzy? Constant adaptation to the cellular environment requires a wide range of changes in protein structure and interactions. Conformational ensembles of disordered proteins in particular exhibit large shifts to activate or inhibit alternative pathways. Fuzziness is critical for liquid–liquid phase separation and conversion of biomolecular condensates into fibrils. Interpretation of these phenomena presents a challenge for the classical structure-function paradigm. Here I discuss a multi-valued formalism, based on fuzzy logic, which can be applied to describe complex cellular behavior of proteins.
- University of Padua Italy
- University of Debrecen Hungary
- Univesity of Debrecen Hungary
Models, Molecular, Amyloid, Protein Conformation, Proteins, Proto-Oncogene Proteins c-mdm2, Intrinsically Disordered Proteins, context-dependence; fuzzy complexes; fuzzy logic; intrinsically disordered proteins; protein–protein interactions; Amyloid; Cytoskeleton; Escherichia coli; Fuzzy Logic; Humans; Intrinsically Disordered Proteins; Models, Molecular; Protein Binding; Protein Conformation; Protein Interaction Mapping; Proteins; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Tumor Suppressor Protein p53, Fuzzy Logic, Protein Interaction Mapping, Escherichia coli, Humans, Tumor Suppressor Protein p53, Review Articles, Cytoskeleton, Protein Binding, Signal Transduction
Models, Molecular, Amyloid, Protein Conformation, Proteins, Proto-Oncogene Proteins c-mdm2, Intrinsically Disordered Proteins, context-dependence; fuzzy complexes; fuzzy logic; intrinsically disordered proteins; protein–protein interactions; Amyloid; Cytoskeleton; Escherichia coli; Fuzzy Logic; Humans; Intrinsically Disordered Proteins; Models, Molecular; Protein Binding; Protein Conformation; Protein Interaction Mapping; Proteins; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Tumor Suppressor Protein p53, Fuzzy Logic, Protein Interaction Mapping, Escherichia coli, Humans, Tumor Suppressor Protein p53, Review Articles, Cytoskeleton, Protein Binding, Signal Transduction
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