Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm
Copyright policy )Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm
AbstractPrevious data showed that complexin I, a SNARE regulatory protein, is localized in and/or around the acrosome and is necessary for the acrosome reaction in sperm. To understand how complexin I regulates the acrosome reaction, we used complexin‐GST pulldown assays to identify interacting proteins. We showed that both complexins I and II bound mouse sperm dynamin 2. Dynamin 2 is a 100 kDa GTPase essential to many aspects of endocytosis but its potential role in exocytosis is unknown. Dynamin 2 is expressed in rat testis and widely expressed in other tissues; however, the function of dynamin 2 in germ cells is uncertain. Dynamin 2 protein was detected in mouse testis and was most abundant in or around the developing acrosome of spermatids. In addition, dynamin 2 was co‐localized with complexin I in the acrosomal region of mammalian sperm. Its co‐localization and interaction with complexin I suggest that dynamin 2 may play a role during acrosome formation and/or acrosomal exocytosis. Mol. Reprod. Dev. 74: 750–757, 2007. © 2006 Wiley‐Liss, Inc.
- University of Wisconsin System United States
- University of Wisconsin–Oshkosh United States
- University of Illinois at Urbana–Champaign United States
- University of Illinois System United States
- University of Wisconsin–Madison United States
Male, Mice, Inbred ICR, Swine, Acrosome Reaction, Nerve Tissue Proteins, Spermatozoa, Sperm Maturation, Adaptor Proteins, Vesicular Transport, Dynamin II, Mice, Testis, Animals, Acrosome, Protein Binding
Male, Mice, Inbred ICR, Swine, Acrosome Reaction, Nerve Tissue Proteins, Spermatozoa, Sperm Maturation, Adaptor Proteins, Vesicular Transport, Dynamin II, Mice, Testis, Animals, Acrosome, Protein Binding
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