Frequent truncating mutations of STAG2 in bladder cancer
Copyright policy )Frequent truncating mutations of STAG2 in bladder cancer
Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
- National Institute of Health Pakistan
- University of California, San Francisco United States
- Johns Hopkins Medicine United States
- National Cancer Institute United States
- Leiden University Netherlands
Mice, Inbred BALB C, Mice, Nude, Antigens, Nuclear, Cell Cycle Proteins, Article, Mice, Gene Frequency, Urinary Bladder Neoplasms, Codon, Nonsense, Cell Line, Tumor, Animals, Humans, Female, Neoplasm Invasiveness, Urothelium
Mice, Inbred BALB C, Mice, Nude, Antigens, Nuclear, Cell Cycle Proteins, Article, Mice, Gene Frequency, Urinary Bladder Neoplasms, Codon, Nonsense, Cell Line, Tumor, Animals, Humans, Female, Neoplasm Invasiveness, Urothelium
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