A novel cDNA isolated from the mouse eye lens encoding a protein with zinc fingers and a KRAB domain
Copyright policy )A novel cDNA isolated from the mouse eye lens encoding a protein with zinc fingers and a KRAB domain
A cDNA clone, pMLZ-8, was isolated from a newborn mouse eye lens cDNA library using a consensus zinc finger oligonucleotide hybridization probe. The cDNA contains an open reading frame that conceptually encodes a 606 amino acid protein. The protein possesses a "KRAB" domain at its amino-terminus and has a carboxy-terminal region with fifteen consensus C2H2 zinc fingers. PCR analysis reveals the presence of pMLZ-8 mRNA in lens, liver, kidney, spleen, and brain of newborn mice.
- National Institute of Health Pakistan
- National Eye Institute United States
- National Institutes of Health United States
DNA, Complementary, Base Sequence, Molecular Sequence Data, Zinc Fingers, Crystallins, Polymerase Chain Reaction, Mice, Open Reading Frames, Animals, Newborn, Consensus Sequence, Animals, Tissue Distribution, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
DNA, Complementary, Base Sequence, Molecular Sequence Data, Zinc Fingers, Crystallins, Polymerase Chain Reaction, Mice, Open Reading Frames, Animals, Newborn, Consensus Sequence, Animals, Tissue Distribution, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
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