Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer
Copyright policy )Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer
Emerging evidences show that circadian rhythm disorder is an important factor of tumor initiation and development. Neuronal PAS domain protein2 (NPAS2), which is the largest circadian gene, has been proved to be a novel prognostic biomarker in breast cancer and non-Hodgkin's lymphoma. However, the potential functions of NPAS2 in colorectal cancer are still unknown. In our present study, we detected the mRNA expressions of NPAS2 in 108 CRC patients by RT-PCR, and found that NPAS2 expression was significantly down-regulated in tumor tissues than that in NATs. Clinicopathologic analysis revealed that low expression of NPAS2 was associated with the tumor size, TNM stage and tumor distance metastasis in colorectal cancer (p0.05). In conclusion, our study suggested that NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer.
- Shanghai Jiao Tong University China (People's Republic of)
- First Affiliated Hospital of Soochow University China (People's Republic of)
- Ruijin Hospital China (People's Republic of)
- Soochow University China (People's Republic of)
Male, Nerve Tissue Proteins, Middle Aged, Prognosis, Cell Line, Tumor, Basic Helix-Loop-Helix Transcription Factors, Humans, Female, Neoplasm Invasiveness, Gene Silencing, RNA, Messenger, Neoplasm Metastasis, Colorectal Neoplasms, Cell Proliferation
Male, Nerve Tissue Proteins, Middle Aged, Prognosis, Cell Line, Tumor, Basic Helix-Loop-Helix Transcription Factors, Humans, Female, Neoplasm Invasiveness, Gene Silencing, RNA, Messenger, Neoplasm Metastasis, Colorectal Neoplasms, Cell Proliferation
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