Genome sequence of the Brown Norway rat yields insights into mammalian evolution
Copyright policy )Genome sequence of the Brown Norway rat yields insights into mammalian evolution
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.
- University of British Columbia Canada
- University of Arizona United States
- Wellcome Trust United Kingdom
- Baylor College of Medicine United States
- European Molecular Biology Laboratory Germany
576.5, Male, Models, Molecular, RNA, Untranslated, Murine Endogenous Retrovirus, 0601 Biochemistry and Cell Biology, Mice, Models, Gene Duplication, Mouse Genome, Conserved Sequences, Base Composition, Genome, Embryonic Epsilon-globin, Animal-model, Untranslated, Single Nucleotide, Genomics, Telomere, Artificial Chromosome Library, Mitochondrial, Multidisciplinary Sciences, Segmental Duplications, Major Urinary Proteins, Sequence Analysis, 570, Retroelements, 572, Evolution, Centromere, 610, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Chromosomes, Evolution, Molecular, Animals, Humans, Polymorphism, Nucleic Acid, Locus-control Region, Mammalian, Molecular, DNA, 06 Biological Sciences, Chromosomes, Mammalian, Introns, Rats, Inbred BN, Dna-sequence, Mutagenesis, DNA Transposable Elements, RNA, CpG Islands, RNA Splice Sites, Regulatory Sequences, ddc: ddc:576.5
576.5, Male, Models, Molecular, RNA, Untranslated, Murine Endogenous Retrovirus, 0601 Biochemistry and Cell Biology, Mice, Models, Gene Duplication, Mouse Genome, Conserved Sequences, Base Composition, Genome, Embryonic Epsilon-globin, Animal-model, Untranslated, Single Nucleotide, Genomics, Telomere, Artificial Chromosome Library, Mitochondrial, Multidisciplinary Sciences, Segmental Duplications, Major Urinary Proteins, Sequence Analysis, 570, Retroelements, 572, Evolution, Centromere, 610, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Chromosomes, Evolution, Molecular, Animals, Humans, Polymorphism, Nucleic Acid, Locus-control Region, Mammalian, Molecular, DNA, 06 Biological Sciences, Chromosomes, Mammalian, Introns, Rats, Inbred BN, Dna-sequence, Mutagenesis, DNA Transposable Elements, RNA, CpG Islands, RNA Splice Sites, Regulatory Sequences, ddc: ddc:576.5
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