Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival
Copyright policy )Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival
Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2 + or Cr2 null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2 null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.
- University of Maryland, Baltimore United States
- University of Maryland School of Medicine United States
- Harvard University United States
- Australian National University Australia
Male, B-Lymphocytes, Cell Survival, Molecular Sequence Data, Gene Expression, Receptors, Antigen, B-Cell, Mice, Transgenic, Germinal Center, Lymphocyte Activation, Adoptive Transfer, Mice, Receptors, Complement 3b, Animals, Female, Immunization, Muramidase, Receptors, Complement 3d, Amino Acid Sequence, Cell Division, Spleen
Male, B-Lymphocytes, Cell Survival, Molecular Sequence Data, Gene Expression, Receptors, Antigen, B-Cell, Mice, Transgenic, Germinal Center, Lymphocyte Activation, Adoptive Transfer, Mice, Receptors, Complement 3b, Animals, Female, Immunization, Muramidase, Receptors, Complement 3d, Amino Acid Sequence, Cell Division, Spleen
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