Current Opinion in Genetics & Development
Article . 2001 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Of flies and men — studying human disease in Drosophila
Authors: A, Bernards; I K, Hariharan;
pmid: 11377963
Of flies and men — studying human disease in Drosophila
Abstract
During the past year, the Drosophila genome has been sequenced. More than 60% of genes implicated in human disease have Drosophila orthologues. Developments in RNA-mediated interference and homologous recombination have made 'reverse genetics' feasible in Drosophila. Conventional Drosophila genetics is being used increasingly to place human disease genes of unknown function in the context of functional pathways.
Related Organizations
- Harvard University United States
Keywords
Drosophila melanogaster, Animals, Humans, Disease, Genetic Predisposition to Disease
Drosophila melanogaster, Animals, Humans, Disease, Genetic Predisposition to Disease
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citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).51 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
popularity
Popularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
51
Top 10%
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