VHL gene mutations in renal cell carcinoma: Role as a biomarker of disease outcome and drug efficacy
Copyright policy )VHL gene mutations in renal cell carcinoma: Role as a biomarker of disease outcome and drug efficacy
The therapeutic landscape for renal cell carcinoma (RCC) has changed drastically over the past several years with the emergence of molecularly targeted therapies. With previous prognostic and predictive tools based on studies of patients treated with cytokine therapies, confirmation of these prior methods and discovery of new markers in this new era of targeted therapy are of great importance. Alteration of the von Hippel-Lindau gene (VHL) by mutation, loss of heterozygosity, and promoter methylation has been found to be important to RCC pathogenesis. In this review, we discuss the potential role of VHL mutation as a prognostic and predictive marker for RCC.
- UNC Lineberger Comprehensive Cancer Center United States
- University of North Carolina at Chapel Hill United States
Vascular Endothelial Growth Factor A, Von Hippel-Lindau Tumor Suppressor Protein, Mutation, Biomarkers, Tumor, Humans, Prognosis, Carcinoma, Renal Cell, Kidney Neoplasms
Vascular Endothelial Growth Factor A, Von Hippel-Lindau Tumor Suppressor Protein, Mutation, Biomarkers, Tumor, Humans, Prognosis, Carcinoma, Renal Cell, Kidney Neoplasms
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