A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
Copyright policy )A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
ABSTRACT The formation of boundaries between groups of cells is a universal feature of metazoan development. Drosophila fringe modulates the activation of the Notch signal trans-duction pathway at the dorsal-ventral boundary of the wing imaginal disc. Three mammalian fringe-related family members have been cloned and characterized: Manic, Radical and Lunatic Fringe. Expression studies in mouse embryos support a conserved role for mammalian Fringe family members in participation in the Notch signaling pathway leading to boundary determination during segmentation. In mammalian cells, Drosophila fringe and the mouse Fringe proteins are subject to post-translational regulation at the levels of differential secretion and proteolytic processing. When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination.
- College of New Jersey United States
- Rutgers, The State University of New Jersey United States
Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Glycosyltransferases, Membrane Proteins, N-Acetylglucosaminyltransferases, Nervous System, Mice, Hexosyltransferases, Glucosyltransferases, Multigene Family, Animals, Drosophila Proteins, Humans, Insect Proteins, Intercellular Signaling Peptides and Proteins, Drosophila, Amino Acid Sequence, Protein Processing, Post-Translational, Body Patterning
Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Glycosyltransferases, Membrane Proteins, N-Acetylglucosaminyltransferases, Nervous System, Mice, Hexosyltransferases, Glucosyltransferases, Multigene Family, Animals, Drosophila Proteins, Humans, Insect Proteins, Intercellular Signaling Peptides and Proteins, Drosophila, Amino Acid Sequence, Protein Processing, Post-Translational, Body Patterning
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