Ongoing Adaptive Evolution of ASPM , a Brain Size Determinant in Homo sapiens
Copyright policy )Ongoing Adaptive Evolution of ASPM , a Brain Size Determinant in Homo sapiens
The gene ASPM ( abnormal spindle-like microcephaly associated ) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution.
- University of Maryland, College Park United States
- University of Chicago United States
- Howard Hughes Medical Institute United States
Recombination, Genetic, Polymorphism, Genetic, Genotype, Models, Genetic, Pan troglodytes, Adaptation, Biological, Gene Conversion, Black People, Brain, Nerve Tissue Proteins, Organ Size, Biological Evolution, Linkage Disequilibrium, Asian People, Gene Frequency, Haplotypes, Animals, Humans, Selection, Genetic, Phylogeny
Recombination, Genetic, Polymorphism, Genetic, Genotype, Models, Genetic, Pan troglodytes, Adaptation, Biological, Gene Conversion, Black People, Brain, Nerve Tissue Proteins, Organ Size, Biological Evolution, Linkage Disequilibrium, Asian People, Gene Frequency, Haplotypes, Animals, Humans, Selection, Genetic, Phylogeny
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