Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats
Copyright policy )Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats
The objective of this study was to evaluate the effects of aging on the performance of specific memory-related tasks in rats as well as to determine the levels of several nerve growth factor (NGF)-related proteins in relevant brain regions. The results indicated age-related impairments in spatial learning in a water maze task as well as deficits in recognition memory in a Spontaneous Novel Object Recognition task. In the prefrontal cortex and hippocampus, aged rats (compared to young controls) had elevated levels of the proneurotrophin, proNGF (+1.8-1.9 fold), p75(NTR) receptors (+1.6-1.8 fold) and sortilin (+1.8-2.1 fold), and decreased levels of mature NGF (-36 to 44%), and phospho-TrkA receptors (-45 to 49%). The results of this study support the argument that NGF signaling is altered in the aging brain, and that such alterations may contribute to an age-related decline in cognitive function. These results may also help to identify specific components of the NGF-signaling pathway that could serve as targets for novel drug discovery and development for age-related disorders of cognition (e.g., Alzheimer's disease).
- VA Southeast Network United States
- Charlie Norwood VA Medical Center United States
- Georgia Regents University United States
Male, Aging, Behavior, Animal, Brain, Prefrontal Cortex, Recognition, Psychology, Hippocampus, Receptor, Nerve Growth Factor, Rats, Adaptor Proteins, Vesicular Transport, Gene Expression Regulation, Nerve Growth Factor, Exploratory Behavior, Animals, Immunoprecipitation, Rats, Long-Evans, Nerve Growth Factors, Protein Precursors, Maze Learning, Psychomotor Performance
Male, Aging, Behavior, Animal, Brain, Prefrontal Cortex, Recognition, Psychology, Hippocampus, Receptor, Nerve Growth Factor, Rats, Adaptor Proteins, Vesicular Transport, Gene Expression Regulation, Nerve Growth Factor, Exploratory Behavior, Animals, Immunoprecipitation, Rats, Long-Evans, Nerve Growth Factors, Protein Precursors, Maze Learning, Psychomotor Performance
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