Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3
pmid: 7578252
Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3
A cDNA encoding a 25-hydroxyvitamin D-3 24-hydroxylase, Cyp-24, has been isolated from mouse kidney cDNA library by hybridization screening. Mouse Cyp-24, coding for 514 amino acid residues, shared 82.1 and 94.7% amino acid identity with human and rat CYP24s, respectively. Among mouse organs examined, Cyp-24 mRNA could be detected in the kidney. When mice were treated with vitamin D-3, Cyp-24 mRNA was induced in the kidney.
- Osaka University Japan
DNA, Complementary, Base Sequence, Molecular Sequence Data, Kidney, Mice, Cytochrome P-450 Enzyme System, Gene Expression Regulation, Enzyme Induction, Steroid Hydroxylases, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Vitamin D3 24-Hydroxylase, Cholecalciferol
DNA, Complementary, Base Sequence, Molecular Sequence Data, Kidney, Mice, Cytochrome P-450 Enzyme System, Gene Expression Regulation, Enzyme Induction, Steroid Hydroxylases, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Vitamin D3 24-Hydroxylase, Cholecalciferol
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