A genome-wide association study identifies three new risk loci for Kawasaki disease
Copyright policy )A genome-wide association study identifies three new risk loci for Kawasaki disease
We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10(-21)), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10(-11)) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10(-8)). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease.
- Funabashi Municipal Medical Center Japan
- University of California, San Diego United States
- Tohoku University Japan
- University of Tokyo Japan
- Toho University Japan
Genetic Markers, Receptors, IgG, Mucocutaneous Lymph Node Syndrome, Polymorphism, Single Nucleotide, Asian People, Genetic Loci, Case-Control Studies, Humans, Genetic Predisposition to Disease, Genome-Wide Association Study
Genetic Markers, Receptors, IgG, Mucocutaneous Lymph Node Syndrome, Polymorphism, Single Nucleotide, Asian People, Genetic Loci, Case-Control Studies, Humans, Genetic Predisposition to Disease, Genome-Wide Association Study
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