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PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
Copyright policy )NIH| PDZ Domains and AMPA Receptor Function ,
NIH| DEFINING THE ROLE OF CAMKII IN SYNAPTIC PLASTICITY
Roberto Malinow; Song-Hai Shi; Mutsuo Nuriya; Richard L. Huganir; Christopher Wilson; José A. Esteban;
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary and sufficient to relieve a retention interaction and drive receptors into synapses. In contrast, PKA phosphorylation of GluR1 and the activity of calcium/calmodulin-dependent kinase II (CaMKII) were both necessary for receptor incorporation. Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity.
- Johns Hopkins Medicine United States
- Johns Hopkins University United States
- Howard Hughes Medical Institute United States
- Johns Hopkins University School of Medicine United States
- Cold Spring Harbor Laboratory United States
Neuronal Plasticity, Presynaptic Terminals, Excitatory Postsynaptic Potentials, Cyclic AMP-Dependent Protein Kinases, Hippocampus, Synaptic Transmission, Rats, Protein Transport, Animals, Newborn, Calcium-Calmodulin-Dependent Protein Kinases, Mutation, Cyclic AMP, Serine, Protein Kinase A, Animals, Amino Acid Sequence, Receptors, AMPA, Phosphorylation, AMPA receptors, Calcium-Calmodulin-Dependent Protein Kinase Type 2
Neuronal Plasticity, Presynaptic Terminals, Excitatory Postsynaptic Potentials, Cyclic AMP-Dependent Protein Kinases, Hippocampus, Synaptic Transmission, Rats, Protein Transport, Animals, Newborn, Calcium-Calmodulin-Dependent Protein Kinases, Mutation, Cyclic AMP, Serine, Protein Kinase A, Animals, Amino Acid Sequence, Receptors, AMPA, Phosphorylation, AMPA receptors, Calcium-Calmodulin-Dependent Protein Kinase Type 2
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).795 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1% views 35 - 35views
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
Impulse provided by BIP!viewsViews provided by UsageCounts
Views provided by UsageCounts 795
Top 1%
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35
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