Pharmacological characterization of α1-adrenoceptor in mouse iliac artery

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2002 English Publisher:Elsevier BVJournal:European Journal of Pharmacology, volume 456, pages 77-79 (issn: 0014-2999,

Authors: Mari, Shibano; Yoshihisa, Yamamoto; Takahiro, Horinouchi; Yoshio, Tanaka; Katsuo, Koike;

doi: 10.1016/s0014-2999(02)02649-3

pmid: 12450572

Pharmacological characterization of α1-adrenoceptor in mouse iliac artery

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Abstract

Subtypes of alpha(1)-adrenoceptor-mediated contraction to noradrenaline in the mouse iliac artery were determined (pharmaco-mechanically). Prazosin, 2-[2,6-dimethoxyphenoxyethyl]aminomethyl-1,4-benzodioxane hydrochloride (WB 4101) and 5-methylurapidil shifted the concentration-response curve for noradrenaline to the right, giving the pA(2) values of 9.30, 9.55 and 8.71, respectively. 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]-ethyl]-8-azaspiro[4,5]decane-7,9-dione dihydrochloride (BMY 7378) shifted the concentration-response curve for noradrenaline to the right and the pA(2) value was 6.62. These results indicate that the contractile response to noradrenaline in the mouse iliac artery is predominantly mediated by the alpha(1A) -adrenoceptor subtype.

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Tohoku University
Japan
Toho University
Japan

Keywords

Male, Dose-Response Relationship, Drug, Prazosin, In Vitro Techniques, Iliac Artery, Piperazines, Dioxanes, Mice, Norepinephrine, Vasoconstriction, Receptors, Adrenergic, alpha-1, Adrenergic alpha-1 Receptor Antagonists, Animals, Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-Antagonists

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