Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase
Copyright policy )Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase
To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-1 and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain.
- Osaka University Japan
- Osaka Gakuin University Japan
- Hospital for Sick Children Canada
- McMaster-Carr United States
- University of Toronto Canada
Mice, Knockout, Microfilament Proteins, Lim Kinases, Zinc Fingers, Protein Serine-Threonine Kinases, Hippocampus, DNA-Binding Proteins, Kinetics, Mice, Destrin, Actin Depolymerizing Factors, Cerebellum, Synapses, Animals, Phosphorylation, Protein Kinases
Mice, Knockout, Microfilament Proteins, Lim Kinases, Zinc Fingers, Protein Serine-Threonine Kinases, Hippocampus, DNA-Binding Proteins, Kinetics, Mice, Destrin, Actin Depolymerizing Factors, Cerebellum, Synapses, Animals, Phosphorylation, Protein Kinases
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