Structure and Chromosomal Locus of the Mouse Gene Encoding a Cerebellar Purkinje Cell-Specific Helix-Loop-Helix Factor Hes-3
Copyright policy )Structure and Chromosomal Locus of the Mouse Gene Encoding a Cerebellar Purkinje Cell-Specific Helix-Loop-Helix Factor Hes-3
HES-3 is a cerebellar Purkinje cell-specific helix-loop-helix factor structurally related to the products of the Drosophila hairy and Enhancer of split genes. Here, we report the nucleotide sequence and chromosomal locus of the mouse Hes-3 gene. This gene consists of four exons and the exon-intron boundaries are well conserved when compared with those of the mouse Hes-1 and Drosophila hairy genes. Southern blot and interspecies backcross analyses show that the mouse Hes-3 gene is a single-copy gene and is located around position 80 on chromosome 4. Further analysis indicates that this locus is close to the Hes-5 locus, which is different from the Hes-1 locus (position 26 on chromosome 16). These results suggest that the Hes-3 and Hes-5 genes may be clustered on chromosome 4 while the Hes-1 gene is not.
Male, Base Sequence, Genotype, Helix-Loop-Helix Motifs, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, DNA, Introns, DNA-Binding Proteins, Mice, Purkinje Cells, Liver, Mice, Inbred NOD, Basic Helix-Loop-Helix Transcription Factors, Animals, Drosophila, Female, Amino Acid Sequence, Crosses, Genetic
Male, Base Sequence, Genotype, Helix-Loop-Helix Motifs, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, DNA, Introns, DNA-Binding Proteins, Mice, Purkinje Cells, Liver, Mice, Inbred NOD, Basic Helix-Loop-Helix Transcription Factors, Animals, Drosophila, Female, Amino Acid Sequence, Crosses, Genetic
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