Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome
Copyright policy )Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome
This study was designed to determine serum Fetuin-A levels and establish whether serum Fetuin-A level is related with insulin resistance, oxidative stress, ovarian hyperandrogenism and dyslipidemia in women with polycystic ovary syndrome (PCOS). Twenty-two patients with PCOS and twenty-one healthy control women were evaluated in this controlled clinical study. Serum Fetuin-A, lipid fractions, glucose, insulin, malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), superoxide dismutase (SOD) and other hormone (gonadotropins, androgens) levels were measured. The estimate of insulin resistance was calculated by homeostasis model assessment (HOMA-R). The women with PCOS had significantly higher serum fasting glucose, insulin, luteinizing hormone (LH), MDA, Fetuin-A levels, and LH/follicle-stimulating hormone (FSH) ratio, free androgen index (FAI), HOMA-IR than healthy women. However, sex hormone-binding globulin (SHBG) and GSH levels were significantly lower in patients with PCOS compared with controls. Fetuin-A was positively correlated with insulin, HOMA-IR and FAI. Multiple regression analysis revealed that FAI was strong predictor of serum Fetuin-A level. Serum Fetuin-A level was related with insulin resistance and ovarian hyperandrogenism in women with PCOS. These results suggest that Fetuin-A may have a role in triggering the processes leading to insulin resistance and androgen excess in PCOS.
- Pamukkale University Turkey
Blood Glucose, alpha-2-HS-Glycoprotein, insulin blood level, low density lipoprotein cholesterol, hyperandrogenism, androgen blood level, gonadotropin blood level, high density lipoprotein cholesterol, follitropin blood level, insulin resistance, Malondialdehyde, Sex Hormone-Binding Globulin, PCOS, oxidative stress, Insulin, glucose, glutathione, fetuin A, prasterone sulfate, clinical article, adult, malonaldehyde, article, sex hormone binding globulin, testosterone blood level, waist circumference, superoxide dismutase, Glutathione, myeloperoxidase, female, priority journal, Adolescent; Adult; Androgens/blood; Blood Glucose/analysis; Dyslipidemias/complications; Female; Follicle Stimulating Hormone/blood; Glutathione/analogs & derivatives/blood; Humans; Hyperandrogenism/complications; Insulin/blood; *Insulin Resistance; Luteinizing Hormone/blood; Malondialdehyde/blood; *Oxidative Stress; Peroxidase/blood; Polycystic Ovary Syndrome/complications/*physiopathology; Sex Hormone-Binding Globulin/analysis; Superoxide Dismutase/blood; Young Adult; alpha-2-HS-Glycoprotein/*, luteinizing hormone, Androgens, Female, follitropin, Polycystic Ovary Syndrome, Adult, insulin, Adolescent, 610, ovarian hyperandrogenism, androgen, dependent variable, Young Adult, ovary polycystic disease, Humans, controlled study, human, gonadotropin, Dyslipidemias, Peroxidase, Superoxide Dismutase, disease association, dyslipidemia, Insulin resistance, Luteinizing Hormone, independent variable, 620, Fetuin-A, Oxidative Stress, glucose blood level, Oxidative stress, adolescent, protein blood level, testosterone, luteinizing hormone blood level, Follicle Stimulating Hormone, Insulin Resistance, Hyperandrogenism
Blood Glucose, alpha-2-HS-Glycoprotein, insulin blood level, low density lipoprotein cholesterol, hyperandrogenism, androgen blood level, gonadotropin blood level, high density lipoprotein cholesterol, follitropin blood level, insulin resistance, Malondialdehyde, Sex Hormone-Binding Globulin, PCOS, oxidative stress, Insulin, glucose, glutathione, fetuin A, prasterone sulfate, clinical article, adult, malonaldehyde, article, sex hormone binding globulin, testosterone blood level, waist circumference, superoxide dismutase, Glutathione, myeloperoxidase, female, priority journal, Adolescent; Adult; Androgens/blood; Blood Glucose/analysis; Dyslipidemias/complications; Female; Follicle Stimulating Hormone/blood; Glutathione/analogs & derivatives/blood; Humans; Hyperandrogenism/complications; Insulin/blood; *Insulin Resistance; Luteinizing Hormone/blood; Malondialdehyde/blood; *Oxidative Stress; Peroxidase/blood; Polycystic Ovary Syndrome/complications/*physiopathology; Sex Hormone-Binding Globulin/analysis; Superoxide Dismutase/blood; Young Adult; alpha-2-HS-Glycoprotein/*, luteinizing hormone, Androgens, Female, follitropin, Polycystic Ovary Syndrome, Adult, insulin, Adolescent, 610, ovarian hyperandrogenism, androgen, dependent variable, Young Adult, ovary polycystic disease, Humans, controlled study, human, gonadotropin, Dyslipidemias, Peroxidase, Superoxide Dismutase, disease association, dyslipidemia, Insulin resistance, Luteinizing Hormone, independent variable, 620, Fetuin-A, Oxidative Stress, glucose blood level, Oxidative stress, adolescent, protein blood level, testosterone, luteinizing hormone blood level, Follicle Stimulating Hormone, Insulin Resistance, Hyperandrogenism
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