Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies
Copyright policy )Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus; the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Millions of cases and deaths to date have resulted in a global challenge for healthcare systems. COVID-19 has a high mortality rate, especially in elderly individuals with pre-existing chronic comorbidities. There are currently no effective therapeutic approaches for the prevention and treatment of COVID-19. Therefore, the identification of effective therapeutics is a necessity. Terpenes are the largest class of natural products that could serve as a source of new drugs or as prototypes for the development of effective pharmacotherapeutic agents. In the present study, we discuss the antiviral activity of these natural products and we perform simulations against the Mpro and PLpro enzymes of SARS-CoV-2. Our results strongly suggest the potential of these compounds against human coronaviruses, including SARS-CoV-2.
- University of the Americas Chile
- Universidad de las Américas Mexico
- Federal University of Paraná Brazil
- Sam Houston State University United States
- Federal University of Paraiba
natural products, plants, SARS-CoV-2, Terpenes, COVID-19, SARS-CoV, Microbiology, Antiviral Agents, Middle East Respiratory Syndrome Virus, QR1-502, Article, COVID-19 Drug Treatment, Molecular Docking Simulation, MERS-CoV, saponins, Drug Discovery, Humans, viruses, Protease Inhibitors, terpenoid, Coronavirus 3C Proteases
natural products, plants, SARS-CoV-2, Terpenes, COVID-19, SARS-CoV, Microbiology, Antiviral Agents, Middle East Respiratory Syndrome Virus, QR1-502, Article, COVID-19 Drug Treatment, Molecular Docking Simulation, MERS-CoV, saponins, Drug Discovery, Humans, viruses, Protease Inhibitors, terpenoid, Coronavirus 3C Proteases
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