Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis
Copyright policy )Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis
Key Points Epo-induced EpoR internalization is mediated through a novel Cbl/p85/epsin-1 pathway. Mutated EpoR in primary familial and congenital polycythemia patients cannot activate this pathway, exhibiting excessive Epo signaling.
- The University of Texas Southwestern Medical Center United States
Mice, Knockout, Immunoblotting, Ubiquitination, Polycythemia, Endocytosis, Cell Line, Class Ia Phosphatidylinositol 3-Kinase, Adaptor Proteins, Vesicular Transport, Mice, HEK293 Cells, Mutation, Receptors, Erythropoietin, Animals, Humans, RNA Interference, Proto-Oncogene Proteins c-cbl, Erythropoietin, Cells, Cultured, Protein Binding, Signal Transduction
Mice, Knockout, Immunoblotting, Ubiquitination, Polycythemia, Endocytosis, Cell Line, Class Ia Phosphatidylinositol 3-Kinase, Adaptor Proteins, Vesicular Transport, Mice, HEK293 Cells, Mutation, Receptors, Erythropoietin, Animals, Humans, RNA Interference, Proto-Oncogene Proteins c-cbl, Erythropoietin, Cells, Cultured, Protein Binding, Signal Transduction
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