25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
Copyright policy )25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
Significance The lipid 25-hydroxycholesterol (25HC) is produced by immune cells in response to infection. We demonstrate that in addition to interfering with viral entry and replication, 25HC also amplifies the activation of immune cells and increases the production of immune mediators. Furthermore, we show that the presence of 25HC is actually harmful in the setting of infection with influenza because the production of these immune mediators leads to damage to the host. These observations might have particular relevance for understanding the mechanisms behind the high pathogenicity of several recently emerged influenza strains, including the H5N1 “bird flu,” and might have implications for the protection of the host from these virulent strains.
- University of Mary United States
- Seattle Institute for Biomedical and Clinical Research United States
- University of Washington United States
Feedback, Physiological, Inflammation, Transcription, Genetic, Macrophages, Orphan Nuclear Receptors, Proto-Oncogene Mas, Hydroxycholesterols, Mice, Inbred C57BL, Transcription Factor AP-1, Disease Models, Animal, Mice, Poly I-C, Orthomyxoviridae Infections, Influenza, Human, Steroid Hydroxylases, Animals, Humans, Liver X Receptors, Signal Transduction
Feedback, Physiological, Inflammation, Transcription, Genetic, Macrophages, Orphan Nuclear Receptors, Proto-Oncogene Mas, Hydroxycholesterols, Mice, Inbred C57BL, Transcription Factor AP-1, Disease Models, Animal, Mice, Poly I-C, Orthomyxoviridae Infections, Influenza, Human, Steroid Hydroxylases, Animals, Humans, Liver X Receptors, Signal Transduction
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