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Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochromec
Copyright policy ) González-Arzola, K.; Díaz-Moreno, I.; Cano-González, A.; Díaz-Quintana, A.; Velázquez-Campoy, A.; Moreno-Beltrán, B.; López-Rivas, A.; +2 Authors
González-Arzola, K.; Díaz-Moreno, I.; Cano-González, A.; Díaz-Quintana, A.; Velázquez-Campoy, A.; Moreno-Beltrán, B.; López-Rivas, A.; De la Rosa, Miguel A.; Fersht, A.R.;
Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochromec
SignificanceHistone chaperones are key regulators of transcriptional activity in damaged chromatin regions in the DNA damage response. Here we show that cytochromec(Cc) targets the histone chaperone SET/template-activating factor (TAF)-Iβ (SET/TAF-Iβ) in the cell nucleus upon DNA damage, resulting in the blocking of the SET/TAF-Iβ function. Ccis actually translocated into the nuclei of cells treated with specific DNA damage inducers and not upon death-receptor pathway or stress-induced stimuli. Cclocks the domains engaged in histone binding of SET/TAF-Iβ, inhibiting its nucleosome assembly activity. Structural characterization of the complex between Ccand SET/TAF-Iβ provides a valuable template for designing drugs aimed at silencing the oncogenic effect of SET/TAF-Iβ.
Models, Molecular, Magnetic Resonance Spectroscopy, Xenopus, Cytochrome c, Binding, Competitive, Histones, Structure-Activity Relationship, Histone chaperone, Animals, Humans, Histone Chaperones, Cell Nucleus, Cytochromes c, ITC, NMR, Protein Structure, Tertiary, DNA-Binding Proteins, Protein Transport, SET-TAF-Iβ, Camptothecin, DNA Damage, HeLa Cells, Molecular Chaperones, Protein Binding, Transcription Factors
Models, Molecular, Magnetic Resonance Spectroscopy, Xenopus, Cytochrome c, Binding, Competitive, Histones, Structure-Activity Relationship, Histone chaperone, Animals, Humans, Histone Chaperones, Cell Nucleus, Cytochromes c, ITC, NMR, Protein Structure, Tertiary, DNA-Binding Proteins, Protein Transport, SET-TAF-Iβ, Camptothecin, DNA Damage, HeLa Cells, Molecular Chaperones, Protein Binding, Transcription Factors
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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