Human Cytomegalovirus Upregulates Expression of the Lectin Galectin 9 via Induction of Beta Interferon
Copyright policy )Human Cytomegalovirus Upregulates Expression of the Lectin Galectin 9 via Induction of Beta Interferon
ABSTRACTRegulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMVin vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.
- University of Sydney Australia
Galectins, Cytomegalovirus Infections, Host-Pathogen Interactions, Cytomegalovirus, Humans, Interferon-beta, Up-Regulation
Galectins, Cytomegalovirus Infections, Host-Pathogen Interactions, Cytomegalovirus, Humans, Interferon-beta, Up-Regulation
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!