The role of N-acetylglucosaminyltransferases V in the malignancy of human hepatocellular carcinoma
Copyright policy )The role of N-acetylglucosaminyltransferases V in the malignancy of human hepatocellular carcinoma
To investigate the role of N-acetylglucosaminyltransferases V (GnT-V) in the malignancy of human hepatocellular carcinoma (HCC), the GnT-V stably suppressed cell line HepG2 GnT-V/1564 was constructed from HepG2. The proliferation, migration, invasion, metastasis of HepG2 GnT-V/1564 was investigated both in vitro and in vivo. The clinical pathological significance of GnT-V expression was also studied in 140 cases of HCC tissues. This study showed that down-regulation of GnT-V inhibited the proliferation, migration and invasion of the HepG2 cells. In addition, GnT-V expression was shown in 138 cases of 140 (98.6%) HCC samples, in 3 cases of 31 (9.7%) in liver cirrhosis cases and in 1 cases of 20 (5.0%) in normal liver tissues. Besides, a higher level of GnT-V was observed more frequently in the advanced tumors with higher T stage and histological grade. These data suggested that GnT-V expression was positively related with malignancy in HCC and GnT-V may be both a differentiation marker and a potential target for the treatment of HCC.
- Southern Medical University China (People's Republic of)
- Zhujiang Hospital China (People's Republic of)
Liver Cirrhosis, Male, Mice, Inbred BALB C, Carcinoma, Hepatocellular, Liver Neoplasms, Down-Regulation, Mice, Nude, Hep G2 Cells, N-Acetylglucosaminyltransferases, Xenograft Model Antitumor Assays, Mice, Liver, Cell Movement, Animals, Humans, Neoplasm Invasiveness, Neoplasm Grading, Cell Proliferation, Neoplasm Staging
Liver Cirrhosis, Male, Mice, Inbred BALB C, Carcinoma, Hepatocellular, Liver Neoplasms, Down-Regulation, Mice, Nude, Hep G2 Cells, N-Acetylglucosaminyltransferases, Xenograft Model Antitumor Assays, Mice, Liver, Cell Movement, Animals, Humans, Neoplasm Invasiveness, Neoplasm Grading, Cell Proliferation, Neoplasm Staging
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).23 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!