Genetic and cytogenetic studies of the malate dehydrogenases of Drosophila melanogaster

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1979 English Publisher:Springer Science and Business Media LLCJournal:Biochemical Genetics, volume 17, pages 947-956 (issn: 0006-2928, eissn: 1573-4927,

Authors: R A, Voelker; S, Ohnishi; C H, Langley;

doi: 10.1007/bf00504314

pmid: 120196

Genetic and cytogenetic studies of the malate dehydrogenases of Drosophila melanogaster

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Abstract

Genetic and cytogenetic locations of the structural genes for the NAD-dependent malate dehydrogenases have been studied. The mitochondrial form (mMDH) is coded for by a gene (mMdh) found at 62.6 on the third chromosome and included in Df(3R)R14, which includes 90C2-91A3 in the salivary gland chromosomes. Based on its inclusion within several J (Jammed; 2-41.0) deficiencies, the structural gene (cMdh) for the cytoplasmic form (cMDH) was determined to lie in region 31B-E, confirming the earlier finding of Grell. Flies lacking any cMDH activity (cMdhn-gamma 10069/Df(2L)J-der-27) were both viable and fertile.

Related Organizations

National Institute of Health
Pakistan

Keywords

Isoenzymes, Recombination, Genetic, Cytoplasm, Drosophila melanogaster, Genes, Malate Dehydrogenase, Animals, Chromosome Mapping, Mitochondria

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