Localized gene action controlling intestinal neoplasia in mice
Copyright policy )Localized gene action controlling intestinal neoplasia in mice
Mice heterozygous for the Apc Min ( Min ) mutation develop adenomas throughout the intestinal tract. Apc is believed to be involved in cell migration, adhesion, and polarity. Adenoma multiplicity and growth rate are modulated by an unlinked modifier locus, Mom1 . The secretory phospholipase Pla2g2a is a candidate for Mom1 . Here, we investigate the range of action of Apc and Mom1 . Analysis of chimeric Min mice indicates that the actions of both Apc and Mom1 are localized within the cell lineage that gives rise to intestinal tumors.
- University of Wisconsin–Madison United States
- University of Wisconsin Hospital and Clinics United States
- UW Carbone Cancer Center United States
Adenoma, Male, Heterozygote, Genes, APC, Genotype, Chimera, Mice, Inbred Strains, Mice, Transgenic, beta-Galactosidase, Morula, Mice, Mutant Strains, Intestines, Mice, Transplantation, Isogeneic, Phenotype, Intestinal Neoplasms, Mutation, Animals, Female, Crosses, Genetic
Adenoma, Male, Heterozygote, Genes, APC, Genotype, Chimera, Mice, Inbred Strains, Mice, Transgenic, beta-Galactosidase, Morula, Mice, Mutant Strains, Intestines, Mice, Transplantation, Isogeneic, Phenotype, Intestinal Neoplasms, Mutation, Animals, Female, Crosses, Genetic
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