COMT val158met genotype and smooth pursuit eye movements in schizophrenia
Copyright policy )COMT val158met genotype and smooth pursuit eye movements in schizophrenia
The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects.
- King's College London United Kingdom
- University of Copenhagen Denmark
- Reykjavík University Iceland
- University of Copenhagen Denmark
- National University Hospital of Iceland Iceland
Adult, Male, Psychiatric Status Rating Scales, Analysis of Variance, Genotype, DNA Mutational Analysis, Valine, Middle Aged, Neuropsychological Tests, Catechol O-Methyltransferase, Polymorphism, Single Nucleotide, Pursuit, Smooth, Methionine, Ocular Motility Disorders, Gene Frequency, Reaction Time, Schizophrenia, Humans, Female, Genetic Predisposition to Disease
Adult, Male, Psychiatric Status Rating Scales, Analysis of Variance, Genotype, DNA Mutational Analysis, Valine, Middle Aged, Neuropsychological Tests, Catechol O-Methyltransferase, Polymorphism, Single Nucleotide, Pursuit, Smooth, Methionine, Ocular Motility Disorders, Gene Frequency, Reaction Time, Schizophrenia, Humans, Female, Genetic Predisposition to Disease
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!