<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: Comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2009 Italy English Publisher:Elsevier BVJournal:Clinical Immunology, volume 133, pages 238-244 (issn: 1521-6616,

Authors: MURDACA, GIUSEPPE; CONTINI, PAOLA; SETTI M.; CAGNATI P.; LANTIERI, FRANCESCA; INDIVERI, FRANCESCO; PUPPO, FRANCESCO;

doi: 10.1016/j.clim.2009.08.002

pmid: 19762282

handle: 11567/245918

Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: Comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution

- Summary
- Subjects
- Related research
  (202)
- Metrics

tips_and_updates
Recommended

Abstract

We have reported that serum level of soluble HLA-A, -B, -C (sHLA-A,-B,-C) antigens is elevated in HIV-infected subjects and decreases after antiretroviral therapy (HAART). In this study, we measured the levels of soluble HLA-G (sHLA-G) antigens in a cohort of HIV-infected patients before and during HAART. sHLA-G and sHLA-A, -B, -C levels were significantly elevated in HIV-infected subjects as compared with controls before antiretroviral treatment and significantly decreased after 36 months of HAART. sHLA-G levels were correlated with sHLA-A, -B, -C levels, the decrease of plasma HIV-RNA level, the increase of CD4+ T-lymphocyte number and the decrease of CD8+ T-lymphocyte number. These results suggest that the measurement of sHLA-G and sHLA-A, -B, -C antigen serum levels might represent a useful surrogate marker to monitor virological response and immune reconstitution in HIV-positive subjects undergoing HAART treatment.

Country

Italy

Related Organizations

University of Genoa
Italy
Goa University
India

Keywords

Adult, HLA-G Antigens, Male, Sex Characteristics, HLA-A Antigens, Histocompatibility Antigens Class I, HIV Infections, HLA-C Antigens, CD8-Positive T-Lymphocytes, Middle Aged, CD4 Lymphocyte Count, HLA Antigens, HLA-B Antigens, Antiretroviral Therapy, Highly Active, HIV-1, Humans, RNA, Viral, Female, Lymphocyte Count, Biomarkers

Filter by relation

All relations

arrow_drop_down

202 Research products, page 1 of 21

MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo
MHC class I antigen
2017IsRelatedTo

chevron_left
1
2
3
4
5
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	31
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average